To elucidate the mechanism of action (MoA) of ceritinib’s antiproliferative activity in these cells, we applied a systems approach combining both chemical and phosphoproteomics to gain a global view of ceritinib’s target profile and network-wide phosphorylation changes following ceritinib treatment.
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: Chemical proteomics ; phosphoproteomics
Principal Investigators: (in alphabetical order) |
Uwe Rix, Moffitt Cancer Center, N/A |
Submitting User: | ccms |
Kuenzi BM, Remsing Rix LL, Stewart PA, Fang B, Kinose F, Bryant AT, Boyle TA, Koomen JM, Haura EB, Rix U.
Polypharmacology-based ceritinib repurposing using integrated functional proteomics.
Nat. Chem. Biol. 2017 Dec;13(12):1222-1231. Epub 2017 Oct 9.
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