MassIVE MSV000096072

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Chemoproteomics analysis revealed photodynamic therapy (PDT) effect of Novel Photo-switchable Photosensitizer

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Description

The study titled "Dyad system of BOAHY-BODIPY Conjugates as Novel Photo-switchable Photosensitizer for Photodynamic Therapy" investigated the photodynamic therapy (PDT) potential of a compound that switches structures (Z form to E form) under UV irradiation. The compound generates reactive oxygen species (ROS) when exposed to light, with the Z form producing more ROS than the E form, leading to higher cytotoxicity. Chemoproteomics analysis revealed more protein modifications in the Z form, indicating greater ROS-induced changes compared to the E form. This suggests that the PDT effect and photo-switching ability can significantly impact biological processes, influencing genetic modifications and highlighting its potential in unbiased biomarker discovery for PDT studies. [doi:10.25345/C5707X10Z] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Chemoproteomics ; photodynamic therapy (PDT) ; reactive oxygen species (ROS) ; Photo-switchable Photosensitizer ; DatasetType:Proteomics

Contact

Principal Investigators:
(in alphabetical order) 		Jun-Seok Lee, Korea University College of Medicine, republic of korea
Submitting User: KyungTae
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