MassIVE MSV000085009

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Quantitative proteomics links the LRRC59 interactome to mRNA translation on the ER membrane

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Description

Hannigan et al. characterize the protein interactomes of four ER ribosome-binding proteins using TMT-based proteomics, providing evidence that ER-bound ribosomes reside in distinct molecular environments. Their data link SEC62 to ER redox regulation and chaperone trafficking, and suggest a role for LRRC59 in SRP-coupled protein synthesis. [doi:10.25345/C5BM3Z] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Tandem Mass Tags ; LRRC59 ; BirA ; translation ; mRAN ; Sec61B

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Principal Investigators:
(in alphabetical order) 		Dr. Christopher Nicchitta, Duke University, United States of America
Dr. J. Will Thompson, Duke University, United States of America
Submitting User: willthompson
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