MassIVE MSV000092808

Partial Public

GNPS - CD38 regulates ovarian function and fecundity via NAD metabolism

Description

Mammalian female reproductive lifespan is typically significantly shorter than life expectancy and is associated with a decrease in ovarian NAD levels. However, the mechanisms underlying this loss of ovarian NAD are unclear. Here, we show that CD38, a NAD consuming enzyme, is expressed in the ovarian extrafollicular space, primarily in immune cells, and its levels increase with reproductive age. Reproductively young mice lacking CD38 exhibit larger primordial follicle pools, elevated ovarian NAD levels, and increased fecundity relative to wild type controls. This larger ovarian reserve results from a prolonged window of follicle formation during early development. However, the beneficial effect of CD38 loss on reproductive function is not maintained at advanced age. Our results demonstrate a novel role of CD38 in regulating ovarian NAD metabolism and establishing the ovarian reserve, a critical process that dictates a female reproductive lifespan. [doi:10.25345/C5251FW3Q] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: ovarian NAD metabolism

Contact

Principal Investigators:
(in alphabetical order)
Eric Verdin, Buck Institute for Research on Aging, United States
Submitting User: Prasanna
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GNPS content goes here (MSV000092808 [task=30dcda32355c46e88e33413bae2d56e6])
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