MassIVE MSV000085040

Partial Public

Effect of senolytics (Navitoclax, ABT263) on recovery following Myocardial Infarction

Description

Ischemia reperfusion injury (IRI) following intervention for myocardial infarction remains an unmet clinical problem. Using an established mouse model, we demonstrated that IRI induces multiple cardiac cell linages to senescence. Senescence is is detrimental to recovery, as treatment with the senolytic navitoclax improves functional recovery.Here we are using SWATH-MS to investigate the molecular mechanisms responsible for the effect of navitoclax treatment. [doi:10.25345/C59H6R] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Mouse, heart, SWATH, myocardial infarction, senolytics, Navitoclax

Contact

Principal Investigators:
(in alphabetical order)
Gavin Richardson, Newcastle University, United Kingdom
Submitting User: Rep_sci
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