MassIVE MSV000093522

Complete Public PXD047348

Itaconate modulates immune responses via inhibition of peroxiredoxins

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Description

Itaconate is a natural mild electrophile, able to modify free thiols in proteins upon activation. We submit two datasets investigating peptides modified by itaconate. Experiment001 contains data obtained from endogenous itaconate producing WT or itaconate incompetent Irg1-/- Bone marrow-derived macrophages stimulated with LPS for 24h. The second dataset from Experiment002 contains data obtained from WT Bone marrow-derived macrophages treated with media or 5 mM itaconic acid for 16h. [doi:10.25345/C51G0J54F] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Itaconylation ; thiol modification ; peroxiredoxin inhibition

Contact

Principal Investigators:
(in alphabetical order) 		Maxim N Artyomov, Washington University, School of Medicine, St Louis, MO, USA
Submitting User: jimmalone
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