Here, we investigated the performance of DIA-MS on a cohort of urines collected from prostate cancer patients against DDA-MS. The performance of several commonly used DIA-MS analysis approaches were examined with our cohort-specific spectral libraries, library-free and a pan-human library. An enhanced prostate cancer urine spectral library was generated for improved proteomic coverage.
[doi:10.25345/C5DF6KD88]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: mass spectrometry ; data-independent acquisition ; data-dependent acquisition ; prostate cancer ; spectral library ; urine
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Dr. Thomas Kislinger, Princess Margaret Cancer Centre, Canada |
Submitting User: | TKislinger |
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