The mammalian mitochondrial rhomboid protease PARL is a critical regulator of mitochondrial homeostasis through its cleavage of substrates such as PINK1, PGAM5, and Smac, which have roles in mitochondrial quality control and apoptosis. Here are the LC-MS/MS data of Multiplex substrate profiling results for mitochondrial PARL in support for the manuscript "Insights into the catalytic properties of the mitochondrial rhomboid protease PARL".
[doi:10.25345/C5BX2P]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: rhomboid protease ; PARL ; mitochondria ; proteolysis ; intramembrane proteolysis ; GlpG ; Parkinson disease ; Protease specificity ; membrane protease
Principal Investigators: (in alphabetical order) |
Anthony O'Donoghue, University of California, San Diego, United States |
Submitting User: | Zhenze |
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