Protein aggregation of amyloid beta peptides and tau are pathological hallmarks of Alzheimer's disease (AD), which are often resistant to detergent extraction and thus enriched in the insoluble proteome. However, additional proteins that co-accumulate in the detergent-insoluble AD brain proteome remain less studied. Here we comprehensively characterized key proteins and pathways in the detergent-insoluble proteome from human AD brain samples by differential extraction, coupled with tandem mass tags labeling and two-dimensional liquid chromatography tandem mass spectrometry (TMT-LC/LC-MS/MS).
[doi:10.25345/C5BR8MS00]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: Alzheimer's Disease ; Neurodegenerative Disease ; Insoluble Proteome ; Splicing ; Proteomics ; Mass spectrometry ; Tandem Mass Tag ;
Principal Investigators: (in alphabetical order) |
Junmin Peng, St. Jude Children's Research Hospital, United states |
Submitting User: | Masih_2021 |
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Owner | Reanalyses | |
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