MassIVE MSV000092403

Partial Public PXD043687

Multiple Omics Analyses of Hispanic Hepatocellular Carcinoma

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Description

Multi-omics approaches were utilized to comprehensively analyze the molecular characteristics of hepatocellular carcinoma (HCC) in South Texas (STX) Hispanics. Exome sequencing revealed high mutation frequencies of AXIN2 and CTNNB1, suggesting a predominant activation of the Wnt/beta-catenin pathway. Cell cycles were positively-, and liver functions were negatively-enriched on gene set enrichment analysis of our transcriptomic and proteomic datasets. Enrichments of gene sets representing specific liver metabolic pathways were found to be associated with the dysregulation of corresponding metabolites. Significant reduction of the majority of lipids seen in serum samples of HCC patients and many fatty acids in HCC tumors corroborate negative adipogenesis and lipid metabolism enrichments. We identified two subtypes of HCC using enrichment scores from paired tumor-nontumor samples of STX-Hispanics or TCGA-LIHC. The subtype with better overall survival revealed pronounced positive enrichments of immune-, angiogenesis-, and negative enrichments of liver function-related hallmark gene sets than the other. The former had higher levels of immune checkpoint and immune exhaustion markers. Together, we report molecular features of HCC, specific and non-specific to Hispanics. [doi:10.25345/C5WH2DR0B] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: hepatocellular carcinoma ; South Texas Hispanics ; multi-omics

Contact

Principal Investigators:
(in alphabetical order) 		Lu-Zhe Sun, University of Texas Health Science Center at San Antonio, United States
Submitting User: stweintraub
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