MassIVE MSV000089551

Partial Public

Mechanical loading but not insertion into an enthesis is required for initiaion of myotendinous junction development

Description

Data files included in this submission are from 4 separate experiments to show that myotendinous junction formation and muscle maturation is dependent on muscle contraction. For Tbx3 E14.5 and E18.5 CS and IN samples: forelimbs (n=3 each genotype and age) were fractionated into C, N, M, CS, and IN fractions and proteins in CS and IN were identified by shotgun proteomics. For Tbx3 P21 and mdg E18.5 samples: samples were homogenized in high-molar urea and proteins were identified by shotgun proteomics. [doi:10.25345/C5QF8JP42] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Tbx3 ; Myotendinous junction ; extracellular matrix ; musculsar dysgenesis (mdg) ; ulnar-mammary syndrome

Contact

Principal Investigators:
(in alphabetical order)
Sarah Calve, Colorado University Boulder, United States
Submitting User: jacobs98

Publications

Lipp SN, Jacobson KR, Colling HA, Tuttle TG, Miles DT, McCreery KP, Calve S.
Mechanical loading is required for initiation of extracellular matrix deposition at the developing murine myotendinous junction.
Matrix Biol. Epub 2023 Jan 26.

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Identification Results
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