The etiology of the inflammatory bowel diseases, including ulcerative colitis, remains incomplete, but recent findings points to the involvement of complex host-microbial interactions. We hypothesized that an analysis of the proteins on the host-microbial interacting surface, the intestinal mucosa, could reveal novel insights into the diseases. Mucosal colonic biopsies were extracted by standard colonscopy from sigmoideum from 10 ulcerative colitis patients from non-inflammed tissue and 10 controls. The biopsies were immediately following extraction snap-frozen for protein analysis and the protein content of the biopsies was characterized by high-throughput quantative gel-free proteomics.
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: Human ; colon ; biopsies ; control ; healthy ; ulcerative ; colitis ; LC-MS ; Q Exactive
Principal Investigators: (in alphabetical order) |
Allan Stensballe, Laboratory for Medical Mass pectrometry Department of Health Science and Tecnology Aalborg University Denmark, N/A |
Submitting User: | ccms |
Bennike TB, Ellingsen T, Glerup H, Bonderup OK, Carlsen TG, Meyer MK, Bøgsted M, Christiansen G, Birkelund S, Andersen V, Stensballe A.
Proteome Analysis of Rheumatoid Arthritis Gut Mucosa.
J. Proteome Res. 2017 Jan 6;16(1):346-354. Epub 2016 Sep 27.
Bennike TB, Carlsen TG, Ellingsen T, Bonderup OK, Glerup H, Bøgsted M, Christiansen G, Birkelund S, Stensballe A, Andersen V.
Neutrophil Extracellular Traps in Ulcerative Colitis: A Proteome Analysis of Intestinal Biopsies.
Inflamm. Bowel Dis. 2015 Sep;21(9):2052-67.
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