Reactive Oxygen Species increase gradually with aging and Steadily diminish the cell's ability to maintain homeostasis. Nuclear Factor-like 2 and its C elegans ortholog, SKN-1 are transcription factors that play a pivotal role in oxidative stress response, cellular homeostasis and lifespan. But like other defence systems, Nrf2-mediated stress response is compromised in aging and neurodegenerative diseases. In this study we provide evidence that this FDA-approved drug is a bona fide activator of Nrf2/SKN-1 pathway.
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: c Elegans ; SILAC ; Label-free ; Proteomics
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Dr Hamid Mirzaei, UT Southwestern Medical center, USA |
Submitting User: | am6390 |
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Owner | Reanalyses | |
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