We report the targeted analysis of the human dental pulp stroma and the odontoblast layer using the positional proteomics technique TAILS N-terminomics, which allowed us to capture both naturally blocked and unblocked protein N-termini, and to identify differences between e.g. the dental pulp proteomes of older and younger donors. Noteworthy, these differences were most pronounced in the odontoblast region. Note: This study is a follow-up on PXD002264.
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: LC-MSMS ; human ; pulp ; stroma ; odontoblast ; CHPP ; TAILS ; N-terminomics ; positional proteomics
|Principal Investigators:||Prof. Christopher Mark Overall, Centre for Blood Research, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC, Canada, N/A|
Abbey SR, Eckhard U, Solis N, Marino G, Matthew I, Overall CM.
The Human Odontoblast Cell Layer and Dental Pulp Proteomes and N-Terminomes.
J. Dent. Res. 2018 Mar;97(3):338-346. Epub 2017 Oct 16.
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