Dynamic nuclear SUMO modifications play essential roles in orchestrating cellular responses to proteotoxic stress, DNA damageand DNA virus infections. Here, we describe the host SUMOylation response to the nuclear-replicating RNA pathogen, influenz A virus. Using quantitative proteomics to compare SUMOylation responses to various stresses (including heat-shock), we reveal that influenza A virus infection causes unique re-targeting of SUMO1 and SUMO2 to a diverse range of host proteins involved in transcription, mRNA processing, RNA quality control and DNA damage repair. This global characterization of influenza virus-triggered SUMO remodeling provides a proteomic resource to understand host nuclear SUMOylation responses to infection.
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: SUMO ; influenza ; heat-shock ; virus ; infection ; ubiquitin ; stress
Principal Investigators: (in alphabetical order) |
Benjamin Geoffrey Hale, Institute of Medical Virology University of Z�rich Winterthurerstrasse 190 8057 Z�rich Switzerland, N/A |
Submitting User: | ccms |
Domingues P, Golebiowski F, Tatham MH, Lopes AM, Taggart A, Hay RT, Hale BG.
Global Reprogramming of Host SUMOylation during Influenza Virus Infection.
Cell Rep. 2015 Nov 17;13(7):1467-80. Epub 2015 Nov 5.
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