MassIVE MSV000089554

Partial Public

Proteome Analysis of TGAC8 and WT mouse Left Ventricles

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Description

Four LV samples from WT and TGAC8 mouse hearts were analyzed. A subset of 8 muscle samples each corresponding to 4 controls and 4 TGAC8 LVs and one averaged reference sample were labeled with 10-plex tandem mass spectrometry tags (TMT) using standard TMT labeling protocol (Thermo Fisher). TGAC8 labeling: TMT-126; TMT-127N; TMT-127C; TMT-130N WT labeling: TMT-128N; TMT-128C; TMT-129N TMT-129C [doi:10.25345/C5B56D83M] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: ADCY8 ; cardiac restricted overexpression ; left ventricle

Contact

Principal Investigators:
(in alphabetical order) 		Kirill V Tarasov, NIA/NIA/LCS, United States
Submitting User: tarasovkv

Publications

Kirill V Tarasov, Khalid Chakir, Daniel R Riordon, Alexey Lyashkov, Ismayil Ahmet, Maria Grazia Perino, Allwin Jennifa Silvester, Jing Zhang, Mingyi Wang, Yevgeniya O Lukyanenko, Jia-Hua Qu, Miguel Calvo-Rubio Barrera, Magdalena Juhaszova, Yelena S Tarasova, Bruce Ziman, Richard Telljohann, Vikas Kumar, Mark Ranek, John Lammons, Rostislav Bychkov, Rafael de Cabo, Seungho Jun, Gizem Keceli, Ashish Gupta, Dongmei Yang, Miguel A Aon, Luigi Adamo, Christopher H Morrell, Walter Otu, Cameron Carroll, Shane Chambers, Nazareno Paolocci, Thanh Huynh, Karel Pacak, Robert Weiss, Loren Field, Steven J Sollott, Edward G Lakatta.
A remarkable adaptive paradigm of heart performance and protection emerges in response to the constitutive challenge of marked cardiac-specific overexpression of adenylyl cyclase type 8.
https://doi.org/10.7554/eLife.80949.

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Number of distinct biological replicates across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct technical replicates across all analyses (original submission and reanalyses) associated with this dataset.

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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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