Four LV samples from WT and TGAC8 mouse hearts were analyzed. A subset of 8 muscle samples each corresponding to 4 controls and 4 TGAC8 LVs and one averaged reference sample were labeled with 10-plex tandem mass spectrometry tags (TMT) using standard TMT labeling protocol (Thermo Fisher).
TGAC8 labeling: TMT-126; TMT-127N; TMT-127C; TMT-130N
WT labeling: TMT-128N; TMT-128C; TMT-129N TMT-129C
[doi:10.25345/C5B56D83M]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: ADCY8 ; cardiac restricted overexpression ; left ventricle
Principal Investigators: (in alphabetical order) |
Kirill V Tarasov, NIA/NIA/LCS, United States |
Submitting User: | tarasovkv |
Kirill V Tarasov, Khalid Chakir, Daniel R Riordon, Alexey Lyashkov, Ismayil Ahmet, Maria Grazia Perino, Allwin Jennifa Silvester, Jing Zhang, Mingyi Wang, Yevgeniya O Lukyanenko, Jia-Hua Qu, Miguel Calvo-Rubio Barrera, Magdalena Juhaszova, Yelena S Tarasova, Bruce Ziman, Richard Telljohann, Vikas Kumar, Mark Ranek, John Lammons, Rostislav Bychkov, Rafael de Cabo, Seungho Jun, Gizem Keceli, Ashish Gupta, Dongmei Yang, Miguel A Aon, Luigi Adamo, Christopher H Morrell, Walter Otu, Cameron Carroll, Shane Chambers, Nazareno Paolocci, Thanh Huynh, Karel Pacak, Robert Weiss, Loren Field, Steven J Sollott, Edward G Lakatta.
A remarkable adaptive paradigm of heart performance and protection emerges in response to the constitutive challenge of marked cardiac-specific overexpression of adenylyl cyclase type 8.
https://doi.org/10.7554/eLife.80949.
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