Extracellular matrix proteomic profiling Mass spectrometry characterization illustrated a reprogrammed proteome in response to matrix stiffness, including a core subset of 84 ECM-specific proteins, including various ECM regulators and tissue-associated ECM-related proteins. Further, we observe remodeling of ECM proteome with softer substrates associated with metabolic/mitochondrial network (178 proteins), while with 40 kPa substrate (92 proteins enriched) resulting in networks associated with enrichment of collagen biosynthesis, integrin cell surface interactions, and extracellular matrix organization networks.
[doi:10.25345/C5445HP44]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: extracellular matrix ; ECM ; proteome ; matrix ; biomaterial
Principal Investigators: (in alphabetical order) |
David Greening, Baker Heart & Diabetes Institute, Australia |
Submitting User: | dwgree |
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