MassIVE MSV000096541

Partial Public PXD058306

LC-MS/MS data of specific proteins involved 4-HNE modification in bone formation

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Description

To elucidate the specific proteins involved in bone formation that are modified by 4-HNE, we performed LC-MS-based proteomics analysis. This approach identified several candidate proteins, including MAP kinase-activated protein kinase 3 (MAPK3), plastin-3 (PLS3), and integrin-linked protein kinase (ILK), all of which are implicated in bone formation or osteoblast differentiation. Notably, 4-HNE-modified ILK was significantly elevated in the GPX4-inhibited group (RSL3 treatment) compared to the control group. [doi:10.25345/C5PR7N60H] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Phospholipid peroxidation ; Osteoporosis ; 4-HNE modification ; DatasetType:Proteomics

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Principal Investigators:
(in alphabetical order) 		Rong-Rong He, Jinan university, China
Submitting User: JNU_816
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