Most humans are infected with Epstein-Barr virus (EBV), a cancer-causing virus. While EBV generally persists silently in B lymphocytes, periodic lytic (re-)activation of latent virus is central to its life cycle and to most EBV-related diseases. However, a substantial fraction of EBV-infected B cells and tumor cells in a population is refractory to lytic activation. This resistance to lytic activation directly and profoundly impacts viral persistence and effectiveness of oncolytic therapy for EBV+ cancers. To identify the mechanisms that underlie susceptibility to EBV-lytic activation, we used host protein-expression profiling of separated-lytic and -refractory cells.
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: Epstein-Barr virus ; lytic activation ; proteomic analysis
Principal Investigators: (in alphabetical order) |
Dr Sumita Bhaduri-McIntosh |
Submitting User: | ccms |
Koganti S, Clark C, Zhi J, Li X, Chen EI, Chakrabortty S, Hill ER, Bhaduri-McIntosh S.
Cellular STAT3 functions via PCBP2 to restrain Epstein-Barr Virus lytic activation in B lymphocytes.
J. Virol. 2015 May;89(9):5002-11. Epub 2015 Feb 25.
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