MassIVE MSV000087969

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GNPS - Decoding the metabolomic composition of Punarnava (Boerhavia diffusa L.), a component of Ayurvedic medicines

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Description

Punarnava [Boerhaavia diffusa L.] is a medicinal plant and constituent of several Indian traditional medicines. According to Ayurveda, this plant is a rich source of nutrients. Traditionally, it is used to provide relief against various gastrointestinal disorders, treat wounds, reduce joint pains, and as an anti-stress agent. Despite its pharmacological importance, detailed characterization of the metabolite composition of this plant has not been reported to date. Therefore, we have taken up metabolomic profiling of Punarnava choorna, as part of a larger project of metabolomic profiling of ayurvedic drugs. We carried out a global metabolomic analysis using a high-resolution mass spectrometry to investigate metabolite composition of Punarnava choorna. In total 1747 and 4031 features were identified at MS1 using XCMS in the positive and negative modes, respectively. Using MS2Compound, we identified 1229 and 709 features in the positive and negative modes, respectively. We also identified 362 and 191 metabolites at MS2 level in the positive and negative modes, respectively using the MS2Compound tool. The data were searched against the PlantCyc, KEGG, PhenolExplorer and HMDB databases. A large number of nutritionally important metabolites including amino acids, sugars and vitamins were identified in Purnarnava choorna. Further, the identified metabolites were mapped to their potential protein interactors using BindingDB tool. Highest number of interactions was observed for plant serotonins. The data provides molecular evidence to accelerate the discovery of mode of action of Purnarnava choorna. [doi:10.25345/C5TC3W] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Complementary Medicine, Alternative Medicine, Global Metabolomics, XCMS, MS2Compound

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Principal Investigators:
(in alphabetical order) 		T. S. Keshava Prasad, Yenepoya Research Centre, Yenepoya (Deemed to be University), India
Submitting User: tsk_prasad
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GNPS content goes here (MSV000087969 [task=f8e8e6907de64fc8ad27d1dea3b9a9df])
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