To identify how MYC overexpression remodels the cell surface proteome in a cell autologous fashion and in different cell types, we investigated the impact of MYC overexpression on ~800 surface proteins in three isogenic model cell lines either of B-cell or prostate cell origin that were engineered to contain either high or low MYC.
[doi:10.25345/C5M173]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: Oncogene MYC ; Surfaceome ; Immunotherapy
Principal Investigators: (in alphabetical order) |
James Wells, UCSF, United States |
Submitting User: | kleung |
Chen W, Mou KY, Solomon P, Aggarwal R, Leung KK, Wells JA.
Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy.
Proc Natl Acad Sci U S A.
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